PhD student position in cancer biology: targeting replication stress in cancer

BACKGROUND

You will work on a project aiming to elucidate how cancer cells can cope with high levels of replication stress. A characteristic of many cancers is their high degree of genomic instability, which is thought to be fueled by replication stress. In this project, which is funded by a recently awarded ERC consolidator grant, we aim to unravel how oncogene-induced replication stress is resolved throughout the cell cycle, with a particular focus on mitosis. You will use biochemical microscopy and genetic approaches. Within this project, we, will ultimately validate our findings in patient material and ex vivo cultures of primary tumor material.

Selected Reading

Heijink AM et al. A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity. PNAS 2015. 8;112(49):15160-5.

Hengeveld RC et al. Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability. Dev Cell. 2015. 34(4):466-74.

Fehrmann RS et al. Gene expression analysis identifies global gene dosage sensitivity in cancer. Nat Genet. 2015. 47(2):115-25.

Lafranchi L et al. APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. EMBO J. 2014. 33(23):2860-79.

Requirements

We offer a PhD studentship to an ambitious candidate with a passion for DNA damage signaling and cell cycle biology. The candidate should have the following requirements:
- MSc in (Molecular/Medical) Biology.
- Fluent in English, both spoken and written.
- A background in molecular cell biology is essential.
- Experience in cell cycle or DNA damage signaling, microscopy or genetics is appreciated.
- An enthusiastic, ambitious team player.

Conditions of employment

- A full-time contract (36 hours/week) for initially 4 year, after one year an evaluation is conducted.
- Your salary is € 2.244,- gross per month in the first year up to a maximum of € 2.874- gross per month in the last fourth year (scale PhD).
- The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).
- In addition, the UMCG will offer you 8% holiday pay, an 8.3% end-of-year bonus and a development budget.

The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.

More information
For more information about this vacancy you may contact:?prof. Marcel van Vugt, PhD,m.vugt@umcg.nl (for inquiries only, please do not use for applications).

Additional information

For details of this vacancy visit the original source

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